Bosone worked behind the scenes for the Weber Basin Project and more covertly for the Small Water Projects program that included securing the terminal reservoir on Deer Creek. She sponsored a bill which called for an investigation of the possibilities of Indians managing their own affairs "without supervision and control by the Federal Government." The bill did not pass but the momentum for "termination" continued through the 1950s, resulting in a policy which eventually proved disastrous to those Indian tribes, such as the Southern Paiutes, who were involved.
Reva Bosone considered running for the Senate in 1952 against Arthur Watkins, but decided to try again for the House. The campaign was as intense and bitter as many across the country in these years of Republican resurgence and Cold War paranoia. Bosone was smeared with false charges of receiving kickbacks and being a communist sympathizer. The latter was related to her courageous vote against funding for the CIA. One of only four in the House to do so, Bosone explained that she was not willing to fund an agency which refused to provide information about its use of the funds.